Release date: 2017-07-19 An important research paper published online by the British journal Nature Microbiology on the 16th shows that the rhesus monkeys who survived the Ebola virus infection, although no longer showing symptoms of infection, detected persistent Ebola virus in the body. Infection, and this is very similar to our human response to the virus. Source: Technology Daily
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Persistent Ebola infection refers to a phenomenon in which the virus persists in certain tissues of the person recovering from the disease (such as the eyes, brain, and testicles) but no longer exhibits any symptoms of the disease. The Ebola outbreak in West Africa from 2013 to 2016 was unprecedented in scale and spread. Since then, persistent infections and their long-term effects (such as blindness, headache and joint pain) have been public health. The focus of attention.
In addition to long-term disease symptoms, persistent infections can lead to new infections – there is evidence that people who are cured can still transmit the virus. Therefore, persistent infection is a very serious problem. However, scientists have not been able to study how the Ebola virus spreads in the host and how it persists in survivors because of the lack of suitable animal models.
This time, the research team of the Maryland Army Infectious Diseases Medical Research Institute found that the Ebola virus spreads through blood vessels and can recover from the eyes and brains of rhesus monkeys who survive the Ebola virus infection and no longer show symptoms of infection. And detected in the testes. In the eye, the virus may be present on the surface of macrophages during incubation. The team also found that persistent viral infections were present in monkeys treated with experimental antiviral drugs, suggesting that these possible medical treatment options may not completely eradicate Ebola virus infection.
The researchers said that the experimental model for rhesus monkeys could provide a basis for studying the persistent infection of Ebola virus and related long-term effects, and would facilitate the development of new treatments.
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The Ebola virus itself is difficult to deal with, and it is called "the blackboard eraser of human life". The researchers also found that the rhesus monkeys infected with the virus and "cured" did not completely get rid of the virus. No longer showing symptoms of infection, it does not mean that the virus has been completely eliminated. They are just crouching, perhaps still waiting for the opportunity. Fortunately, researchers can keep an eye on these rhesus monkeys and conduct long-term research on the Ebola virus. However, the follow-up work on survivors of Ebola virus infection may have to be fully implemented as soon as possible. Otherwise, if the virus comes back from them, the consequences are unpredictable.
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