Tablets are convenient for taking, and are a common type of Zui in pharmaceutical preparations, and the die is an indispensable accessory on the tablet press machine commonly used by Zui. It is also very important to choose the right die after the tablet press is purchased. In many tablet manufacturers, the tablet presses that are purchased cannot be used normally due to improper selection of the die. Using zui's new CAD/CAM technology, we select advanced alloy steels, excellent heat treatment technology and scientific testing methods to produce all kinds of dies. 1 There are many types of die dies, but we can distinguish them according to the equipment used, the materials, the standards, and the shapes: 1.3 According to different standards, there are ZP standard (GB12253.90) die, IPT international standard die, EU standard die and various non-standard special compression tablets. Machine die and battery ring die; ( Standard JB/T20080.1-2006 (T series) of high-speed tablet press die recently passed the trial); 1.4 According to the shape of the different points, there are round, shaped, shallow concave, deep concave, oblique side, lettering, engraved, ring; see Figure 1, Figure 2. 2 Some problems should be paid attention to when ordering the die. In order to enable the users of the pharmaceutical factory to order the appropriate die, this article will introduce some of them here. It is also recommended that the drug manufacturer can fully discuss with the die manufacturer to reduce the possibility of production. The problem that arises. 2.1 Due to the track design and some characteristics of the processing technology, it is recommended that the user must purchase the same factory product for the tablet press and the die. 2.3 The problems considered when designing the die, the difference between the depth and angle of the film coating film; the corrosion caused by the material pH to the die; the influence of the traditional Chinese medicine or high fiber raw material on the service life of the die; whether the pattern and typeface will be pressed During the film process, the punching die, the effervescent film, the vitamin C film, the disinfecting film and the like have corrosion effects, and the surface of the die should have a special coating film treatment. Carbide materials should be used for some acidic, easily oxidizable materials. 2.4 Consideration of the number of die: In order to take into account the partial damage during use and the waste in the manufacturing process, it is recommended that the customer order 1.2 times according to the actual production needs; for long-term user suggestions, the first batch of die will be left 1 to 2 new products. As a sample, the sample should always be used as a standard when replenishing the die. 3 The storage and maintenance of the die is very precise. The users of the pharmaceutical factory should establish a special die storage and storage system. The store should be kept dry. After the die is used, it must be removed and cleaned on the tablet press. It should be placed in alcohol or clean olefin oil for cleaning. After the deposit on the die is soft, dry it with cotton cloth and apply anti-rust oil. , placed in a special protective box or in the die storage box placed on the rack, should be marked with the size. Do not mix unused dies with the same size with used dies. Under normal circumstances, after the die is used, in order to ensure the smooth surface of the die, the pharmaceutical factory users can polish themselves and often check for rust, cracks, abrasion and other rust phenomena. 4 Inspection of the die Usually the new die is tested by the manufacturer's inspection department before it leaves the factory, and will be accompanied by documents that prove the quality. The imported die will even have detailed data for each die. However, many pharmaceutical manufacturers now prefer to purchase some low-quality dies at a lower price. This requires the user to perform some necessary tests on the newly purchased dies before the formal use, so as to avoid unnecessary losses. 5 Zui large ultimate load diagram of various types of die The load of various die presses can bear a lot of load, or work under a safe load is a problem that every user pays close attention to. Researchers from foreign tablet presses and die manufacturing found that among many factors, Zui is mainly the die diameter and sheet type. Through a large number of experiments and system analysis, after processing the data, the zui large ultimate load graph of various types of dies shown in Fig. 3 is drawn. The ordinate shown in the figure is expressed as the large allowable load of zui, and the abscissa is expressed as the die diameter of the die. As shown in the figure, the four types are from top to bottom, respectively. (1) flat type; (2) flat type; (3) Shallow concave type; (4) Deep concave type; Zui's large load capacity is: (1) 800 N/mm2; (2) 700 N/mm2; (3) 400 N/mm2; (4) 300 N/mm2. That is to say, the deep concave type die bearing capacity is small, and the Zui is easy to be damaged. On the contrary, the flat die type die bearing capacity is large, and the Zui is not easily damaged. 6 Reasons and solutions for common die damage The die of the tablet press is usually made of alloy tool steel. After several steps of rough finishing, sufficient precision is ensured. Together with the exquisite heat treatment, the corresponding hardness and hardness are guaranteed. Durability. Professional manufacturers have undergone rigorous inspections at the delivery of each die to ensure that the user is a qualified product. However, many users still cause certain damage to the die due to equipment, process, operation and other reasons. Here, we make a simple analysis for the user to refer to: 7 The die of the die verification file is only a component on the tablet press. According to the requirements of the GMP management of the drug, the same IQ, PQ, OQ and other verification procedures must be established as the device to establish the standard operation. , operation, maintenance, maintenance, cleaning and other verification documents, establish a corresponding file for each set of die, from the ordering, trial, production, to the storage of the library must establish a corresponding system. For example, the test procedure: The model number of the test equipment, the machine number, the time of the test run, the type of the test (material), the person responsible for the test run, and the problems encountered during the test run should be fully recorded. In short, it can be traced, there are files to check, reduce costs, extend the life of the die, and ensure the quality of the drug. If you want to know more about die press die , please log in to our company :< > Or direct pharmaceutical technology department : <> consulting, our factory will provide you with more professional services! 2.2 Selection of the chip type: The correct selection of the film type is a successful step of the tablet die. For example, chewable tablets have higher hardness requirements and can be easily chewed. Most of them use beveled flat sheets; those that require film coating can be shallow concave. Because of the absence of binders and lubricants in the raw materials, the medium tablets require a large pressure during tableting, and the sheet type is preferably shallow. For tablets with a large sugar content, the sheet design is preferably shallow or flat. The medium mold can use alloy steel or hard alloy. The deep concave type die is easily damaged and is used as little as possible.
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1.1 According to different equipment used, there are single punching machine die, rotary tableting die, basket type tableting die and press die;
1.2 According to different materials, there are alloy steel die, hard alloy die, ceramic die, chrome plating, titanium-plated die; common die die
Gold steel materials are: GCr15, Crl2MoV, CrWuMn, 9Mn2V, 9CrSi; common materials for imported die zui are: A2, O1, S1, S7, PHG.S, PHG-P.
1.5 Depending on the application, there are tablet dies, effervescent tablet press dies and battery ring dies.
Do not blindly pursue the cheap and buy a poor die, which causes damage to the tablet press.
Similarly, some samples can be tested for the die that has been used for a period of time to determine whether the die is still in a qualified state.
