The efficacy and effect of senna

effect

1, purgative effect of this product on mice, rats, rabbits and other animals and individuals have significant diarrhea, mice and rabbits diarrhea after drug 2-4b, about 6h after oral administration caused by diarrhea . The active ingredients of this product are diarrhea mainly Sennaia A and B, especially Senna Panaxa A. Although there is little content of diarrhea and A phase in Senna P. Sennae A20mg/kg can cause mice to diarrhea. However, if A is mixed with 20% of C, the effect of senna panacea A can be increased by 1.6 times. Senna can be partially absorbed in the small intestine, and then enters the large intestine via blood flow or bile, but mainly enters the large intestine directly from the small intestine. Under the action of intestinal bacteria, it can be hydrolyzed, reduced, etc., and changed into rheinone or rheinone. -8-glucoside. Since the diarrhoea effect of infusion of rheinone was not affected and the production of indolinone was significantly reduced in the intestine, it was considered that flavonone pentane was the real component of diarrhea caused by diarrhea. On the other hand, flipping the small intestine and colonic sciatica can prevent the translocation of glucose and Na across the intestinal wall, indicating inhibition of the intestinal absorption of glucose, sodium, and water, increasing the volume of the intestinal lumen and subsequently stimulating the intestinal wall to reflexically make Increased peristalsis in the small intestine and colon may also be one of its mechanisms of diarrhoea, and the small intestine is also the site of action of its purgative component.

2. Hemostasis is effective for gastric and duodenal bleeding. The product was used to spray the solution of gastric bleeding under gastroscope. There was immediate hemostasis when seen directly. Intraperitoneal injection of total scrotum 200mg/kg can significantly reduce the bleeding time in mice. Oral senna, can increase the number of platelets and fibrinogen, coagulation time, thromboplastin time, plasma recalcification time and clot shortening time. In addition, the product of the hydrochloric acid and indomethacin-induced gastric mucosal damage in rats is also beneficial to the prevention and treatment of gastric and duodenal bleeding.

3. Antibacterial effect Senna extract has inhibitory effects on various bacteria such as E. coli, Proteus, Shigella, Streptococcus aureus, and white rosary and certain pathogenic dermatophytes.

4. Other effects In experimental rats with intestinal obstruction, 50 mg/kg sciatic insult reduced the intestinal mucosal histamine content to normal levels. In addition, it has been reported that the product has an arrow poisonous effect, can block the transmission of nerve-muscle joint impulses, prevent the combination of acetylcholine and M receptors and relax muscles.

5. The LD50 of mice injected with intraperitoneal injection of toxic senna was 1.414g/kg, equivalent to 36.3g/kg crude drug.


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