The role of snake venom

Snake venom is a liquid secreted by viper from the venom gland. The main ingredient is toxic protein, which accounts for about 90% to 95% of dry weight. There are about twenty kinds of enzymes and toxins. In addition, it also contains small peptides, amino acids, carbohydrates, lipids, nucleosides, biogenic amines, and metal ions. The composition of snake venom is very complex. The toxicity, pharmacology and toxicological effects of different snake venoms have their own characteristics. Among them, the toxin shows:
1. Blood circulating toxins (including viper venom, venomous snake venom, iron venom venom, and green snake venom)
2, neurotoxin: (eye venom, golden snake venom, silver venom, eye king venom, rattlesnake venom)
3, mixed toxins: (snake venom, eye venom)
1 The role of snake venom in cancer: Cancer is one of the three major diseases that endanger human health. Currently, there is no effective therapy. Scientists from all over the world are using snake venom as a new area for the safety education of the venom. China Snake Lab, China Medical University From the venom of snake venom produced in Dalian Snake Island, Liaoning Province, we found an effective ingredient that can inhibit tumor growth. We carried out a comparison between the original poison of the snake island snake and the isolated virus and inhibited the tumor test. Nine different concentrations of snake venom had different degrees of sarcoma in mice. Inhibition, some tumor inhibition rates up to 87.1%.
2 The anticoagulant effect of snake venom: Kunming Institute of Zoology, Yunnan, China Defibrase extracted from China's five-step snake venom through technology identification in 1981 for the treatment of vascular thrombosis 333 cases, of which 242 cases of cerebral thrombosis, there are Efficiency 86.4%. The Python antacid enzyme developed by China Medical University and Shenyang Pharmaceutical University has been used to treat vascular occlusive diseases. It has achieved satisfactory clinical results. The venom anaerobic enzyme developed by China National Laboratory of Snake Venom, China Medical University, can reduce blood lipids. It is an ideal anticoagulant thrombolytic agent that dilates blood vessels, reduces blood thromboxanes, increases prostacyclin, and relaxes vascular smooth muscle.
3 The hemostatic effect of snake venom, Japan uses a procoagulant component mentioned from the python, used in clinical surgery, internal medicine, ENT, obstetrics and Gynecology and other bleeding diseases. The drug called "reptile enzyme injection" .
4 Preparation of anti-venom serum: The development of anti-venom serum in China began in the 1930s. After the liberation, Shanghai Institute of Biological Products cooperated with Zhejiang Research Institute of Traditional Chinese Medicine, Zhejiang Institute of Traditional Chinese Medicine, and Guangzhou Medical College to successfully prepare refined anti-viper. , Five-step snake, Coral snake, Eye snake venom serum.
5 The analgesic effect of snake venom: In 1976, Kunming Institute of Zoology, Yunnan Institute of Zoology, successfully developed "Ketongling" for the treatment of various painful diseases, and achieved unique analgesic effect. "The compound gram pain developed by Cao Yisheng" "Ning" has shown very good efficacy in the treatment of neuropathic pain, cancer pain and detoxification. Because snake venom analgesics have a higher analgesic activity and no addiction, clinically used in place of morphine for the treatment of late cancer pain .
The venom of a viper can be prepared with a special anti-venom serum, an analgesic and a hemostatic agent. The effect is better than that of morphine, meperidine and no addiction. Snake venom can also treat lice and poliomyelitis. In recent years snake venom has been used to treat cancer. Because snake venom is composed of 34 proteins, there is a very important and large number of toxins called cytolysin. It is a toxin that specifically destroys cells and cell membranes. This produces a malignant tumor. If the cytotoxin from snake venom is isolated and injected into the body as the blood circulation spreads throughout the body, specifically killing the cancer cells, then it is hopeful to overcome this difficulty in the treatment of cancer. Defibrase for injection is extracted from the venom of Agkistrodon acutus in our country. It has the function of defibrillation and thrombolysis. It is a special drug for treating cardiovascular diseases.
The eight uses of snake venom: 1. Cancer treatment and anti-cancer, anti-tumor; 2. Hemostasis and anticoagulation; 3. Drugs and analgesics; 4. Preparation of anti-venom serum; 5. Scientific research; 6. Lower blood pressure , Defibrillation, thrombolytic; 7, treatment of blood stasis first pass; 8, the application of nerve growth factor.

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