Gene editing for HIV treatment shows hope April 23, 2018 Source: Sina Pharmaceutical Gene therapy has recently undergone a renaissance, and the technology is gradually being accepted by many AIDS researchers. Because the CCR5 gene plays an important role in AIDS resistance, the ability of researchers to manipulate genes (especially CCR5) may help solve problems that have plagued HIV treatment for many years. Often, even if patients respond well to antiretroviral therapy, they tend to hide the HIV "repository", which can be recovered at any time. Fred Hutchinson Cancer Research Center Recently, scientists at the Fred Hutchinson Cancer Research Center in Seattle have come up with convincing results from an animal experiment: genetically edited stem cells extracted from the patient's bone marrow can solve the problem of HIV accumulation. In a study on infection of chimeric marmoset/human immunodeficiency virus (SHIV) macaques, genetically engineered stem cells extracted from bone marrow appeared to reduce viral storage. CCR5 first caught the attention of AIDS researchers in 2007, when an HIV-positive patient named Timothy Brown was cured by bone marrow transplantation. Later, scientists discovered that his bone marrow donor contained a CCR5 mutation that made his cells resistant to HIV infection. The Fred Hutchinson team has previously shown that stem cells can be removed from the macaque's bone marrow and their genes edited to make them resistant to HIV mutations. When they transplant these cells back into the animal, they repopulate. In this new study, the team analyzed tissue samples taken from animals and found that the edited cells invaded the HIV “repositoryâ€. However, according to the paper, these reservoirs are undetectable in two of the animals. Just two months ago, scientists at Case Western Reserve University and Sangamo Therapeutics announced a human trial that will evaluate the effects of genetically engineered T cells on HIV. They will use a zinc finger nuclease gene editing technique to remove CCR5 cells from the patient's blood. The trial is expected to recruit 20 patients. In recent years, AIDS researchers have made progress and unveiled the mystery of the HIV repository. Last year, scientists at the University of North Carolina found that these reservoirs could exist in white blood cells called macrophages, which are different from T cells and can exist in many areas of the body, including bone marrow. The Fred Hutchinson team found that only 4% of white blood cells in the macaques contained CCR 5 editors over time, and the absence of antiretroviral drugs was not sufficient to maintain SHIV relief. They are now working to improve the efficiency of editing techniques and hope to increase the proportion of this therapeutic gene. (Sina Pharmaceutical Compilation / David) Article, image reference source: Gene editing shows promise in combating HIV reservoirs Fruit And Vegetables Cutting Machine fruit and vegetables be cut into clivers, pcs, and cubes Industrial Vegetable Cutting Machine,Vegetable Cutting Machine,Commercial Vegetable Cutting Machine,Fruit Dicing Machine JIANGSU SKYPLAN GREENHOUSE TECHNOLOGY CO.,LTD , https://www.thgreenhouse.com